For Business Use Only. Does Not Ship to Residential Addresses. For use inside an Analyzer, Sold Separately.
Beckman Coulter Access Thyroid Uptake Reagent, 100 Determinations, 2 x 50 tests
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Product Code: 33810
Manufacturer: Beckman Coulter
Shipping Weight: 10.00lbs (4.54kg)
Specifications
Brand: Access®
Manufacturer: Beckman Coulter
Country of Origin: United States
Application: Reagent
Number of Tests: 100 Tests
Test Name: T-Uptake
Test Type: Thyroid / Metabolic Assay
Intended Use
The Access Thyroid Uptake assay is a paramagnetic particle, chemiluminescent immunoassay for the assessment of the thyroxine-binding capacity of unsaturated proteins in serum and plasma, using the Access Immunoassay Systems. This test may also be used in conjunction with a total thyroxine measurement to provide a calculated free thyroxine index (FTI).
Summary and Explanation
The hypothalamo-hypophyseal-thyroid axis controls the synthesis, release and action of triiodothyronine (T3) and thyroxine (T4). More than 99% of the T4 and T3 circulate in the blood bound to carrier proteins leaving less than 1% unbound. The greatest binding affinity for both hormones is to thyroxine-binding globulin (TBG) and, to a lesser extent, to prealbumin (TPBA) and serum albumin. The level of thyroid activity correlates with the unbound or free hormone concentration. Generally, the total T4 is indicative of the amount of free T4 because TBG concentrations remain relatively constant. However, changes in TBG concentration affect the number of unoccupied TBG binding sites thus affecting the level of protein-bound hormone and leaving the free level of hormone unchanged. In hypothyroidism the relatively unsaturated binding proteins reflect a decreased thyroid uptake value. In hyperthyroidism the thyroid uptake value increases due to the highly saturated binding proteins.
The Access Thyroid Uptake assay indirectly assesses the unsaturated binding capacity of certain serum proteins, primarily TBG. This, in conjunction with total T4 measurement, allows for a better estimate of the amount of endogenous circulating thyroid hormone-an indirect indication of thyroid function. Using the thyroid uptake value to provide a measure of relative amounts of unsaturated TBG and the total T4 value to provide the concentration of total hormone, one can indirectly estimate the relative amounts of free T4 present in the sample by means of a free thyroxine index (FTI) calculation.
