For Business Use Only. Does Not Ship to Residential Addresses. For use inside an Analyzer, Sold Separately.
OSRT056 Beckman Lithium Reagent, R1 2 x 16 mL
Easily reorder reagents and American-made parts.
Enjoy the fair price promise.
Take pressure off your budget (and yourself)
Product Code: OSRT056
Manufacturer: Beckman Coulter
Shipping Weight: 10.00lbs (4.54kg)
Specifications
Application: Reagent
Number of Tests: 2 X 113 tests
Test Name: Lithium
Test Type: Therapeutic Drug Monitoring
Volume: 2 X 16 mL
Intended Use
Reagent for the quantitative determination of Lithium concentrations in human serum and plasma on the Beckman Coulter AU® Chemistry analyzers.
About Beckman Lithium
Lithium is widely used in the treatment of manic-depressive psychosis. Administered as Lithium Carbonate, it is completely absorbed by the gastro-intestinal tract, peak serum levels occur 2 to 4 hours after an oral dose. The half-life in serum is 48 to 72 hours and it is cleared through the kidneys (excretion parallels that of sodium). Reduced renal function can prolong clearance time.
Lithium acts by enhancing the uptake of neurotransmitters which produces a sedative effect on the central nervous system. Serum Lithium concentrations are carried out essentially to ensure compliance and to avoid toxicity.
Early symptoms of intoxication include apathy, sluggishness, drowsiness, lethargy, speech difficulties, irregular tremors, myoclonic twitchings, muscle weakness and ataxia. Levels higher than 1.5 mmol/L (12 hours after a dose) indicate a significant risk of intoxication.
Methodology
Lithium can be determined by atomic absorption spectrophotometry, flame emission photometry, or ion-selective electrode. These methods require specific and often dedicated instrumentation.
The Beckman Coulter Lithium reagent is a spectrophotometric method that can be readily adapted to automated clinical chemistry analyzers. Lithium present in the sample reacts with a substituted porphyrin compound at an alkaline pH, resulting in a change in absorbance which is directly proportional to the concentration of Lithium in the sample.
Additional Information
Beckman Lithium - Safety Data Sheet
