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Immunalysis 349UR-0100 EDDP Reagent, 100mL
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Product Code: 349UR-0100
Manufacturer: Immunalysis Corporation
Shipping Weight: 2.00lbs (0.91kg)
Immunalysis 349UR-0100 EDDP Reagent, 100mL
EDDP is the primary metabolite of methadone. It is excreted in the bile and urine together with the other metabolite EMPD. EDDP is formed by N-demethylation and cyclization of methadone in the liver. The part of the unchanged excreted methadone is variable and depends on the urine’s pH value, dose, and the patient’s metabolism. Therefore, detectionof the metabolite EDDP instead of methadone itself is useful because interferences of the patient’s metabolism are avoided, and the detection of EDDP avoids concerns of potential sample adulteration. EDDP can be detected within 4 to 6 hours after use. It can be cleared by the body within 2 to 3 days after use.
Administration: Pill, sublingual tablet, and oral formulations.
Elimination: Methadone has a typical half life of 15 to 55 hours and metabolizes by N-demethylation to its main metabolite, 2-ethylidene-1, 5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and then N-demethylates to its secondary metabolite, 2-ethyl-5-methyl-3,3-diphenylpyrroline (EMDP). The considerable variation in methadone metabolism and excretion is apparently due to genetic variability in the production of the associated enzymes CYP3A4, CYP2B6, and CYP2D6.1-3
Abuse Potential: Methadone is a Schedule II controlled analgesic; it has the potential for being abused and is subject to criminal diversion.
