For Business Use Only. Does Not Ship to Residential Addresses. For use inside an Analyzer, Sold Separately.
Olympus OSR4T229 GENTAMICIN REAGENT, EMIT 2000,R1 2X23ML,R2 2X13ML
Easily reorder reagents and American-made parts.
Enjoy the fair price promise.
Take pressure off your budget (and yourself)
Product Code: OSR4T229
Shipping Weight: 10.00lbs (4.54kg)
Specifications
Manufacturer: Beckman Coulter
Country of Origin: United States
Application: Reagent
Container Type: Bar Coded Cartridge
For Use With: For Olympus AU400, AU400e, AU600, AU640, AU640e, AU680, AU2700, AU5400 Chemistry Analyzers
Number of Tests: 2 Tests
Test Name: Gentamicin
Test Type: Therapeutic Drug Monitoring
UNSPSC Code: 41116007
Intended Use
The Emit® 2000 Gentamicin Plus Assay is a homogeneous enzyme immunoassay intended for use in the quantitative analysis of gentamicin in human serum or plasma. These reagents are packaged specifically for use on a variety of AU® Clinical Chemistry Systems. Measurements obtained from this device are used in the diagnosis and treatment of gentamicin overdose and in monitoring levels of gentamicin to assure appropriate therapy.
About Gentamicin Reagent
Monitoring gentamicin concentrations in serum, along with careful clinical assessment, is the most effective means of ensuring adequate therapy for the following reasons:
• Gentamicin concentration in serum correlates better with antibacterial activity than does dosage.
• A standard dose of gentamicin does not always yield a predictable serum level because the drug’s concentration also depends on the patient’s volume of distribution and on drug elimination. These factors are influenced by the mode of administration, the volume of extracellular fluid, renal function, and physiological changes during therapy.
• Gentamicin has a narrow range of safe and effective serum concentrations.
• Exposure to high concentrations for a prolonged period may cause renal impairment or ototoxicity.
• Patients with impaired renal function should be monitored closely while on gentamicin therapy because nephrotoxicity caused by gentamicin may be difficult to distinguish from the symptoms of underlying renal disease. In addition, patients with compromised renal function eliminate gentamicin more slowly than patients with normal renal function.
• Methods historically used to monitor serum gentamicin concentrations are immunoassays, microbiological assays, and chromatographic assays.
Methodology
The Emit ® 2000 Gentamicin Plus Assay is a homogeneous enzyme immunoassay technique used for the analysis of specific compounds in biological fluids. The assay is based on competition between drug in the sample and drug labeled with the enzyme glucose-6-phosphate dehydrogenase (G6PDH) for antibody binding sites. Enzyme activity decreases upon binding to the antibody, so the drug concentration in the sample can be measured in terms of enzyme activity. Active enzyme converts oxidized nicotinamide adenine dinucleotide (NAD) to NADH, resulting in an absorbance change that is measured spectrophotometrically. Endogenous serum G6PDH does not interfere because the coenzyme functions only with the bacterial (Leuconostoc mesenteroides) enzyme employed in the assay.Additional description
Gentamicin Reagent - Safety Data Sheet
