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OSR6193 Olympus Lactate Reagent
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Product Code: OSR6193
Shipping Weight: 10.00lbs (4.54kg)
Specifications
Manufacturer: Beckman Coulter
Country of Origin: Italy
Application: Reagent
Number of Tests: 4 X 60 Tests
Test Name: Lactate
Test Type: General Chemistry
UNSPSC Code: 41116004
Intended Use
System reagent for the quantitative determination of L-Lactate in human plasma and cerebrospinal fluid (CSF) on Beckman Coulter AU analyzers.
About Lactate Reagent
L-lactate is the end product of anaerobic glycolysis. It is derived predominantly from white skeletal muscle, brain, skin, renal medulla and erythrocytes. Lactate dehydrogenase catalyses the reduction of pyruvate to lactate.
There are two major clinical settings in which lactic acidosis occur:
(1) Conditions associated with hypoxia e.g. shock, congestive heart failure, myocardial infarction, blood loss and pulmonary edema.
(2) Metabolic or drug/toxin related disorders. Examples of metabolic disorders include diabetes mellitus, hepatic disease and neoplasia.
Congenital metabolic disorders include type I glycogen storage disease. Examples of drugs/toxins which give rise to elevated lactate are methanol, ethanol, epinephrine and acetaminophen.
L-lactate levels in CSF will generally mirror those in blood/plasma. However, increased lactate levels in CSF in the absence of increased blood/plasma lactate concentration have been reported in cases of bacterial meningitis, cerebral hypoxia, ischemia and in certain inborn errors of metabolism e.g. pyruvate dehydrogenase deficiency, mitochondrial myopathies and biotinidase deficiency.
Methodology
L-lactate is oxidized to pyruvate and hydrogen peroxide by lactate oxidase (LOD). A colored product is produced by the reaction of peroxidase (POD), hydrogen peroxide, 4 -aminoantipyrine and a hydrogen donor (TOOS). The colored product is measured photometrically. The color intensity is proportional to the concentration of lactate in the sample under examination.
Additional Information
Lactate Reagent - Safety Data Sheet
