For Business Use Only. Does Not Ship to Residential Addresses. For use inside an Analyzer, Sold Separately.
OSR6211 Olympus DBil Reagent (4x200 tests)
Product Code: OSR6211
Shipping Weight: 10.00lbs (4.54kg)
Specifications
Manufacturer: Beckman Coulter
Country of Origin: Ireland
Application: Reagent
Number of Tests: 4 X 200 Tests
Test Name: Direct Bilirubin
Test Type: Hepatic / General Chemistry
UNSPSC Code: 41116004
Volume: 4 X 20 mL
Intended Use
System reagent for the quantitative determination of Direct Bilirubin in human serum and plasma on Beckman Coulter AU analyzers.
*Direct Bilirubin reagent OSR6511 for use on AU2700/5400/680 system only.
About Direct Bilirubin
Bilirubin is an end product of hemoglobin catabolism. It is conjugated with glucuronic acid in the liver, and the conjugated form is cleared from the circulation by excretion in the bile. Both conjugated (direct) and unconjugated (indirect) forms of bilirubin circulate loosely bound to albumin.
The assessment of direct bilirubin is helpful in the determination of hepatic disorders. The increase in the total bilirubin associated with obstructive jaundice is primarily due to the direct fraction. Both direct and indirect bilirubin are increased in the serum with hepatitis. In the newborn patient with hemolytic jaundice and neonatal jaundice, the increase in the total bilirubin is primarily due to the indirect bilirubin fraction. This jaundice may be caused by Rh, ABO, or other blood group incompatibilities, by hepatic immaturity, or by hereditary defects in bilirubin conjugation.
Methodology
This Direct Bilirubin Reagent utilizes a variation of the classical method developed by Van den Bergh and Mueller. Direct (conjugated) bilirubin couples directly with a diazonium salt of 3,5-dichloroaniline (DPD) in an acid medium to form azobilirubin.
The direct bilirubin in serum is directly proportional to the color development of azobilirubin which is measured bichromatically at 570/660 nm.
Additional Information
Direct Bilirubin - Safety Data Sheet
Direct Bilirubin - Instructions for Use