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OSR6295 Olympus HDL Reagent (4x250 tests)
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Product Code: OSR6295
Shipping Weight: 10.00lbs (4.54kg)
Specifications
Manufacturer: Beckman Coulter
Country of Origin: Japan
Application: Reagent
Number of Tests: 4 X 250 Tests
Storage Requirements: Requires Refrigeration
Test Name: Direct High-Density Lipoprotein (HDL) Cholesterol
Test Type: Cardiac / Lipids / General Chemistry
UNSPSC Code: 41116004
Volume: 4 X 50 mL, 4 X 16.5 mL
Intended Use
System reagent for the quantitative determination of HDL-Cholesterol concentrations in human serum and plasma on Beckman Coulter AU analyzers.
About HDL Reagent
Many epidemiological investigations have demonstrated the strong and independent inverse association between HDL-Cholesterol and the risk of coronary artery disease. It has been proposed that HDL particles, through the uptake and transport of Cholesterol from peripheral tissue to the liver (reverse Cholesterol transport), protects against the development of atheromatous plaques.
Under the guidelines issued by The National Cholesterol Education Program Adult Treatment Panel 2 (NCEP ATP 2), it is recommended that both HDL-Cholesterol and Total Cholesterol should be measured in the initial screening for hypercholesterolemia.
In 2001, the NCEP increased the high-risk medical decision point to <40 mg/dL.
The guidelines classify HDL- C levels as follows:
1. < 40 mg/dL as indicative of a major risk factor for Coronary Heart Disease.
2. > 60 mg/dL as a negative risk factor for Coronary Heart Disease.
Methodology
The HDL-Cholesterol test is a two reagent homogenous system for the selective measurement of serum or plasma HDL-Cholesterol in the presence of other lipoprotein particles. The assay is comprised of two distinct phases. In phase one, free cholesterol in non-HDL-lipoproteins is solubilized and consumed by cholesterol oxidase, peroxidase, and DSBmT to generate a colorless end product. In phase two a unique detergent selectively solubilizes HDL- lipoproteins. The HDL cholesterol is released for reaction with cholesterol esterase, cholesterol oxidase and a chromogen system to yield a blue color complex which can be measured bichromatically at 600/700nm. The resulting increase in absorbance is directly proportional to the HDL-C concentration in the sample.
This reagent was tested in a Cholesterol Reference Method Laboratory Network (CRMLN) laboratory to confirm that it meets the guidelines of the NCEP.
Additional Information
HDL Reagent - Safety Data Sheet
