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Thermo Kit Acetamin Cal
Thermo Kit Acetamin Cal
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Product Code: 1091
Manufacturer: Thermo Scientific
Shipping Weight: 2.00lbs (0.91kg)
Specifications
Description: Acetaminophen Calibrator Set
Detectable Analytes: Negative, 10, 25, 50, 100, 200µg/mL
Quantity: 1 x 5mL, 5 x 2mL
Storage Requirements: 2° to 8°C
Intended Use
The DRI® Acetaminophen Serum Tox Assay is intended for the quantitative determination of acetaminophen in human serum or plasma.
Summary and Explanation of the Test
Acetaminophen is an analgesic, which also has an antipyretic effect in humans. It is one of the most popular non-prescription pain relievers available to the public. The toxic side effects associated with acetaminophen include nausea, drowsiness and vomiting. Hepatotoxicity may occur with chronic acetaminophen therapy or when large amounts of the drug are ingested accidentally or in suicide attempts. It has been demonstrated that there is a definite correlation between serum acetaminophen levels and subsequent liver damage. Proper management of acetaminophen overdoses requires early monitoring of acetaminophen serum levels to prevent hepatic necrosis, which is not clinically evident until twelve hours or more after ingestion. Determination of acetaminophen in serum is the most reliable indicator for prognosis and even more important for treatment with antidotes.
Many techniques are available for determination of acetaminophen concentration in serum. These methods include GC, HPLC, enzyme immunoassay, UV spectrometry and fluorescence immunoassay. The DRI Acetaminophen Serum Tox Assay is a homogeneous enzyme immunoassay, which uses ready-to-use liquid reagents. The assay is based on competition between the drug in the serum sample and an enzyme glucose-6-phosphate dehydrogenase (G6PDH) labeled drug for a fixed amount of drug specific antibody binding sites. If the drug is not present in the sample, the drug-G6PDH conjugate is bound by the specific antibody, which results in enzyme inhibition. This phenomenon creates a direct relationship between the drug concentration in the sample and the enzyme activity. The enzyme G6PDH activity is determined spectrophotometrically at 340 nm by measuring its ability to convert nicotinamide adenine dinucleotide (NAD) to NADH.
