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Thermo Kit Creat-Detect 500mL
Thermo Kit Creat-Detect 500mL
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Product Code: 1797
Manufacturer: Thermo Scientific
Shipping Weight: 2.00lbs (0.91kg)
Specifications
Description: DRI Creatinine-Detect SVT
Detectable Analytes: Creatinine
Quantity: 500mL
Storage Requirements: Refrigerated
Intended Use
The DRI® Creatinine-Detect® Test is intended for the quantitative determination of creatinine in human urine for the detection of urine adulteration by dilution or substitution with nonurine solution.
Summary and Explanation of the Test
A complete urine drug of abuse testing program normally involves specimen collection, initial screening with an immunoassay, followed by a confirmation test, such as gas chromatography/mass spectrometry (GC/MS), for positive samples. Many drug users attempt to evade detection by adulterating their specimen in order to produce false negative results during the initial immunoassay screening. Adulteration methods include dilution with water, substitution with a drug free liquid, addition of readily available household materials (e.g., vinegar, baking soda, liquid drain opener, detergent, etc.) or tampering with certain chemicals (e.g., Urine-Aid, which contains glutaraldehyde or Klear, which contains potassium nitrite).
Several methods have been used to detect urine adulteration. These methods include measuring the temperature, pH, specific gravity and creatinine concentration of the sample. Fresh normal urine should have the following typical characteristics: temperature between 32.5-37.7°C or 90.5-99.8°F, pH within 4.7-7.8, specific gravity within a range of 1.003-1.035 g/mL and creatinine concentration of 80-200 mg/dL. If any of these urine parameters is outside the specified range, there should be reason to believe that the urine sample has been adulterated.
Creatinine is secreted from muscle into urine daily. In the absence of renal disease, rate of creatinine clearance in an individual is relatively constant. Dilution of urine with water or any other non-urine solution can result in a lower creatinine concentration.
DRI Creatinine-Detect Test can be performed on automated clinical chemistry analyzers to measure creatinine concentration. This method is based on the Jaffe reaction, whereby creatinine concentration is determined colorimetrically using alkaline picrate to form a reddish Janovski complex according to the following equation:
